Eefjan Breukink

Prof. Eefjan Breukink is a Professor in the Department of Membrane Biochemistry & Biophysics within the Biomolecular Sciences School at Utrecht University. His research focuses on bacterial cell wall synthesis and membrane biochemistry, particularly targeting antibiotic development. Key areas include lipid II transport mechanisms, lantibiotic action modes, and overcoming Gram-negative bacterial outer membrane barriers. His work integrates biochemical, structural, and biophysical approaches to uncover novel antibiotic strategies.

• Expertise: Cell wall biosynthesis, antimicrobial peptides, membrane protein interactions
• Key Projects: HT screening for outer membrane-targeted antibiotics, lipid II analog screening

Research explores synergistic antibiotic effects under stress conditions and mechanisms of host defense peptides. Collaborations include the Fungal Biodiversity Centre (KNAW) for natural product antibiotic discovery.