Ebrahim Zandi

Dr. Ebrahim Zandi is Associate Professor of Molecular Microbiology & Immunology at USC's Keck School of Medicine. A PEW Scholar and founding director of the USC Proteomics Center, his research spans NF-κB signaling, cancer proteomics, and microbiome interactions.

Key Discoveries

Seminal contributions include:

• Identification of IKK complex components and phosphorylation mechanisms
• Hydrogen sulfide regulation of T-cell differentiation via Foxp3 demethylation
• Development of PDI inhibitors for ovarian cancer therapy

Current work applies proteomics to microbiome function in ulcerative colitis and cancer immunotherapy.

Technical Innovation

Pioneered mass spectrometry methods for post-translational modification detection (InsPecT algorithm) and multiplex biomarker quantification for neurodegenerative diseases.