Douglas Ruden

Douglas Ruden is a Professor and Director of Epigenomics at the Institute of Environmental Health Sciences, Wayne State University. With joint appointments in the Departments of Pharmacology and Biology, he specializes in epigenetic mechanisms linking environmental exposures to genomic changes.

• Teaches graduate courses in genetics, epigenetics, and bioinformatics
• Uses Drosophila, Daphnia, and human stem cells for toxicological studies
• Laboratory techniques include BS-Seq, Infinium, ChIP-Seq, and mDIP-Seq
• Collaborates with the Applied Technology Genomics Core

His research focuses on how early-life lead exposure alters DNA methylation and histone modifications, with applications in neurodevelopmental studies, cancer biology, and environmental health. Publications highlight transgenerational epigenetic inheritance and endocrine disruptor effects across model organisms.