Don Zack

Don Zack is a Professor of Ophthalmology at Johns Hopkins University, specializing in retinal biology and neurodegenerative disorders. His research focuses on molecular mechanisms underlying retinal function, disease pathology, and therapeutic interventions.

Key research areas include CRX transcription factor regulation, photoreceptor gene expression, and retinal neovascularization. Collaborations with labs such as Peter Campochiaro (AMD/diabetic retinopathy) and Harry Quigley (glaucoma) highlight his interdisciplinary approach. His work bridges basic science and clinical translation, aiming to develop diagnostic and treatment strategies for retinal diseases.

Dr. Zack’s lab employs transgenic models, molecular biology techniques, and biochemical analyses to study retinal degeneration mechanisms. Recent studies include CRX gene mutation impacts on Leber congenital amaurosis, VEGF-driven neovascularization, and apoptosis inhibition in glaucoma.