Denis Kaynov

Denis Kaynov is a Professor at the Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Norway. He received his doctorate from the University of Helsinki in 2005 and held postdoctoral positions at the Institute of Genetics and Molecular and Cellular Biology (IGBMC) (2005–2007) and CRP-Santé Luxembourg (2007–2009). From 2010–2016, he served as a researcher and project manager at the University of Helsinki before joining NTNU.

• Education
  • Doctorate, University of Helsinki (2005)
• Affiliations
  • Professor, NTNU (2016–present)
  • Former researcher, University of Helsinki (2010–2016)
  • Postdoctoral researcher, IGBMC (2005–2007) and CRP-Santé Luxembourg (2007–2009)
• Research Interests
  • Virology: Broad-spectrum antivirals, virus-host interactions, SARS-CoV-2, enteroviruses, hepatitis viruses, drug combinations, and resistance mechanisms.
  • Pharmacology: Drug discovery, repurposing, and synergistic combinations targeting viral replication and host pathways (e.g., JAK-STAT, TMPRSS2).
  • Immunology: Innate immunity, interferon responses, and immune barriers to viral propagation.
• Article Trends
  • Focus on antiviral drug combinations to combat resistance, with applications in SARS-CoV-2, enteroviruses, and gastric adenocarcinoma.
  • Development of organoid models for studying virus-host interactions and therapeutic testing (e.g., macrophage-augmented intestinal organoids).
  • Investigation of host factors like importin α1 and TMPRSS2 in viral infections, and computational approaches for drug repositioning.
• Collaborators
  • Key collaborators include Hilde Lysvand, Aleksandr Ianevski, Valentyn Oksenych, and others across institutions in Norway, Finland, and Luxembourg.
• Teaching & Outreach
  • Active in training and mentoring through academic publications and collaborations on platforms like DrugVirus.info, which serves as a portal for broad-spectrum antivirals and drug combinations.