Davide Bruno

Davide Bruno is a researcher at Liverpool John Moores University, actively contributing to the field of neuropsychology with a focus on ageing, dementia, and memory. His work bridges clinical research and cognitive neuroscience, particularly in the early detection of Alzheimer’s disease through cognitive and biomarker assessments.

His research interests include:

• Ageing and cognitive decline
• Alzheimer’s disease biomarkers (CSF, plasma, PET)
• Memory assessment (story recall, AVLT, logical memory)
• Neuroinflammation and microglial activation
• Impact of depression and hormonal factors on brain health
• Digital cognitive biomarkers for early detection

Davide Bruno's recent publications reveal a strong trend in utilizing story recall and episodic memory metrics to predict Alzheimer’s pathology, often in collaboration with international cohorts. His work increasingly integrates plasma and CSF biomarkers with neuropsychological performance, aiming to develop sensitive, non-invasive tools for early diagnosis. He also explores the intersection of mental health (depression, loneliness) and neurodegeneration.

Notable scientific contributions include studies on:

• Proper name recall as an early indicator of preclinical Alzheimer’s
• Sex differences in memory decline
• Impact of menopausal hormone therapy on AD biomarkers
• Neuroinflammatory markers in late-life depression

Bruno has been involved in advising through collaborative research, particularly in longitudinal studies like the Wisconsin Registry for Alzheimer’s Prevention. He has contributed to research on cognitive reserve, executive function, and the effects of multimodal training. His work often involves cross-institutional collaborations, particularly with teams in the US and Europe.

He is associated with research labs and teams focused on:

• Neurodegeneration and dementia
• Cognitive ageing
• Neuroinflammation in depression
• Digital biomarker development