David Williams

Dr. David Williams holds the Carroll H. Long Chair of Excellence for Surgical Research at the Department of Surgery, leading research initiatives focused on immunity, sepsis, and infectious diseases. His work emphasizes host-pathogen interactions, trained immunity mechanisms, and translational therapies for conditions like cerebral adrenoleukodystrophy and parasitic infections. Supported by NIH grants, his research spans cellular biology, metabolic pathways, and drug discovery.

Research Interests: Dr. Williams investigates innate immune memory mechanisms, sepsis pathophysiology, and the role of metabolic adaptations in immunity. His studies include inflammatory responses in cardiovascular diseases, therapeutic targeting of parasitic enzymes, and β-glucan-based immunomodulation strategies. He also explores the molecular underpinnings of cell senescence and organ crosstalk during critical illness.

• Key Projects:
• Gene therapy for cerebral adrenoleukodystrophy (CALD)
• Thioredoxin reductase inhibitors for寄生虫 diseases
• Trained immunity in aging and sepsis

Awards:

• Carroll H. Long Chair of Excellence (2017-present)

Labs & Affiliations: Kleinman Laboratory of Ocular Biology and Imaging, collaborating on ocular immunology and imaging technologies. Active in cross-departmental initiatives to enhance surgical research education and clinical translation.