David Tremethick

Professor David Tremethick leads the Chromatin and Transcriptional Regulation group at the John Curtin School of Medical Research, Australian National University. His lab investigates epigenetic mechanisms—particularly histone variants like H2A.Z—that regulate chromatin architecture, gene expression, and RNA processing during development and disease.

Key research areas include 3D genome organization, epigenetic control of cell differentiation, and links between histone misincorporation and cancer. Recent work employs genome mapping, CRISPR editing, and biochemical approaches to dissect how histone variants influence chromatin compaction and splicing.

Publications demonstrate a focus on H2A.Z's roles in development, cancer (e.g., Hodgkin lymphoma), and neurological function. Methodological innovation is evident in studies combining chromatin immunoprecipitation, isotope labeling, and advanced imaging.

Major projects include investigations into histone variant functions in spermatogenesis and brain development using mouse models. No awards, students, or lab details are explicitly documented in provided texts.