About
Professor David Samuels is a renowned academic at Newcastle University, specializing in mitochondrial genetics and neurology. His research focuses on understanding the genetic mechanisms of mitochondrial DNA mutations, their clinical implications in diseases like spinocerebellar ataxia, and the epidemiology of mitochondrial disorders. He has collaborated extensively with peers such as Patrick Chinnery and Joanna Elson across multiple studies.
Key areas of research include the genetic bottleneck effect, mitochondrial mutation transmission, and the role of epigenetics in disease expression. His work bridges basic science with clinical applications, addressing challenges like preventing pathogenic mtDNA mutations through germ-line gene therapy.
Samuels has contributed to studies on mitochondrial DNA dynamics, including the role of genetic drift in oocytes and the formation of deletions in mtDNA. His research also extends to superfluid helium physics, showcasing interdisciplinary interests. His findings have been published in high-impact journals, with notable collaborations spanning genetics, epidemiology, and computational biology.