David Pellman

David Pellman, M.D., is the Margaret M. Dyson Professor of Pediatric Oncology at Dana-Farber Cancer Institute and a Professor of Cell Biology at Harvard Medical School. He is also an HHMI Investigator and Associate Director for Basic Science at the Dana-Farber/Harvard Cancer Center. His research focuses on cell division mechanisms and their roles in cancer genome evolution, including studies on spindle positioning, cytokinesis, nuclear envelope assembly, and mutational processes like chromothripsis. Pellman's lab employs advanced techniques such as live-cell imaging and single-cell genome sequencing (Look-Seq) to link cell division errors to genomic alterations.

Education: B.A./M.D. from the University of Chicago, postdoctoral training at Whitehead Institute/MIT. Key awards include HHMI Investigatorship.

Research Interests:

• Mechanisms of cell division and genome integrity
• Chromothripsis and other mutational processes
• Nuclear envelope architecture and function
• Cytoplasmic chromatin and innate immunity

Grants & Funding: Principal Investigator on NIH grants including R35CA293978 (Mechanisms Driving Cancer Genomes), R37GM061345 (Cell Cycle-Cytoskeleton Control), and R01CA213404 (Polyploidy/Aneuploidy).

Awards:

• Howard Hughes Medical Institute Investigator

Labs/Teams: Pellman Lab at Dana-Farber Cancer Institute, specializing in imaging and genomic analysis of cancer evolution.