David H. Farrell

David H. Farrell is a Professor in the Department of Surgery at Oregon Health & Science University School of Medicine, specializing in hemostasis and thrombosis research. His work bridges basic protein biochemistry with clinical trauma and critical care applications, with particular focus on fibrinogen biology and coagulopathy in traumatic brain injury and infectious disease.

His research interests center on Blood Coagulation, Fibrinogen Biology, Hemostasis and Thrombosis, and Protein Biochemistry, with recent emphasis on γ′ fibrinogen's role in COVID-19 pathophysiology and trauma-induced coagulopathy. Dr. Farrell's laboratory investigates molecular mechanisms of fibrin polymerization, fibrinogen splice variants, and their clinical implications in thrombotic and hemorrhagic disorders.

His publication trends reveal consistent focus on fibrinogen isoforms (particularly γ′ variants) across multiple clinical contexts including traumatic brain injury, trauma resuscitation, and viral infections. Recent work demonstrates how γ′ fibrinogen levels serve as biomarkers for disease severity in both trauma and COVID-19, with implications for targeted anticoagulant therapy.

Honors include:

• Fellow of the American Heart Association
• Editorial Board Member of Journal of Hematology

Dr. Farrell maintains active research collaborations across trauma surgery, neurosurgery, and critical care units at OHSU, with particular focus on translating coagulation biomarker discoveries into clinical practice through trauma protocols and diagnostic applications. His work with the International Fibrinogen Research Society and International Society on Thrombosis and Haemostasis drives global standardization in fibrinogen research methodologies.