David Grayson

Professor David Grayson is a faculty member in the Department of Chemistry at Trinity College Dublin, where he conducts research in organic synthesis and heterocyclic chemistry. His work emphasizes the development of new synthetic methodologies, particularly involving sulfonyl-stabilized anions, vinylic sulfones, and chiral auxiliaries derived from monoterpenoids.

Research Interests: His research spans Organic Synthesis, Asymmetric Synthesis, Heterocyclic Chemistry, and Natural Product Synthesis, with a focus on medium- and macrocyclic lactones. He has made significant contributions to the chemistry of 4-dimethylaminopyridine N-oxide derivatives and the functionalization of terpenoid scaffolds such as camphor.

The recent publications (2009–2018) reflect a strong trend toward medicinal chemistry applications, including the synthesis of bioactive guanidines, kinase inhibitors (e.g., 9-azapaullones), and precursors to antihistamines like Claritin. Many studies leverage chiral terpenoid frameworks for stereoselective synthesis, demonstrating ongoing innovation in asymmetric methodologies.

Scientific Recognition:

• CChem FRSC (Chartered Chemist, Fellow of the Royal Society of Chemistry), 1982

Advising and Collaborations: Professor Grayson has mentored and collaborated with several researchers, including F. W. Lewis, J. W. Shaw, I. Rozas, and E. T. Gallagher, indicating active supervision of graduate students and postdoctoral researchers. While no formal grant information is listed, his sustained publication record over four decades suggests long-term research funding and academic engagement.

Laboratories and Research Environment: Although no named lab or research group is specified, his extensive publication history in synthetic organic chemistry implies leadership of a research group within the Chemistry Department at Trinity College Dublin.