David Forrest

David Forrest is a Research Fellow in the Department of Biosciences at the University of Birmingham. His research focuses on bacterial chromosome biology, particularly mechanisms of transcriptional regulation, gene expression, and the interplay between chromatin organization and DNA sequence features. He collaborates extensively with groups studying microbial pathogenesis and horizontal gene transfer.

Key research areas include bidirectional promoters in Salmonella plasmids, nucleoid organization in E. coli, and the role of RNA polymerase in xenogeneic silencing. His work integrates high-throughput genomic approaches with molecular genetics to elucidate fundamental principles of prokaryotic gene regulation.

Recent studies have explored transposon capture mechanisms mediated by H-NS proteins and the environmental regulation of chromatin structure. Forrest’s contributions advance understanding of bacterial adaptation and pathogenicity through detailed analyses of transcriptional landscapes and genetic architecture.