David Cachia

David Cachia is a Professor in the Department of Medicine at UMass Chan Medical School, affiliated with the T.H. Chan School of Medicine's Hematology/Oncology division. He earned his MD from the University of Malta Medical School in Malta. His research focuses on neuro-oncology, particularly brain tumors such as meningiomas, glioblastoma, and ependymomas, with an emphasis on clinical trials, molecular mechanisms, and translational therapies. He has contributed to over 100 peer-reviewed publications and collaborates with multidisciplinary teams including neurosurgery, radiology, and oncology.

Key research areas include targeted therapies for NF2-related tumors, caregiver support in neuro-oncology, and optimizing treatment protocols for recurrent high-grade gliomas. His work bridges basic science (e.g., drug sensitivity studies) with clinical practice (e.g., phase II trials). Notable collaborations include the RANO-Cares working group and the Alliance A071401 trial initiative.

Publications span topics like imaging biomarkers, EEG features in metastatic brain tumors, and standardized tissue preservation methods. He actively participates in institutional tumor boards for rare CNS tumors and explores synergistic drug combinations to enhance glioblastoma treatment efficacy.