David Aylor

David Aylor is an Associate Professor in the Department of Biological Sciences at North Carolina State University (NC State), serving as Deputy Director of the Center for Human Health and the Environment (CHHE). His affiliations include the Bioinformatics Center, Functional Genomics, Genetics and Genomics Academy (GGA), and Toxicology & Environmental Health Sciences programs. His research focuses on epigenomics, gene-environment interactions, and environmental health, with a strong emphasis on developmental and neurobiology aspects of toxicant exposure. Aylor’s work employs mouse models and large-scale genetic consortia like the Collaborative Cross to study complex traits and disease mechanisms. His contributions span from molecular mechanisms of disease to population-level toxicokinetic studies, integrating genomic and environmental data to understand health outcomes.

Key research themes include the impact of early-life environmental exposures on epigenetic aging, genetic modifiers of stroke outcomes in mouse models, and the role of Aryl Hydrocarbon Receptor (AHR) variants in human health. Aylor’s work also explores the genetic basis of pluripotency in stem cells and hybrid sterility in house mice. He is actively involved in interdisciplinary collaborations, such as the NIEHS TaRGET II Consortium for environmental epigenomics and the Personalized Environment and Genes Study (PEGS).

Aylor’s recent work highlights trends in environmental epigenetics, systems genetics, and translational toxicology. His articles bridge molecular mechanisms with population-level health impacts, emphasizing the importance of genetic variation in mediating environmental exposures. Awards and grants are not explicitly listed, but his research is supported through institutional and consortium-based funding. He advises students and collaborates extensively on projects involving mouse models and genomic analysis platforms. Aylor’s lab and affiliated teams at CHHE focus on advancing precision health and environmental risk assessment.