David A. Spiegel

David A. Spiegel is a Professor of Chemistry at Yale University, with secondary appointments in Pharmacology and Molecular Medicine. His research focuses on the intersection of organic chemistry, pharmacology, and synthetic immunology, developing novel small molecules for biomedical applications.

• Yale School of Medicine
• Chemistry
• Pharmacology
• Molecular Medicine
• Global Health Studies
• Yale Cancer Center

Research Interests: Dr. Spiegel’s work spans medical chemistry, synthetic immunology, and chemical biology. He explores methods for targeted protein degradation, antibody recruitment, and metabolic disease mechanisms. His lab designs bioactive compounds for cancer, infectious diseases, and neurodegenerative conditions.

Recent Publications: His recent studies address tumor growth via YAP signaling, brain-targeted drug delivery, and synthetic strategies for immunomodulation. Key themes include glycation, transcytosis, and small molecule-based therapies.

Scientific Awards:

• Alfred P. Sloan Foundation Fellowship
• NIH Director’s New Innovator Award
• Camille and Henry Dreyfus New Faculty Award
• Ellison Foundation New Scholar Award
• Bill and Melinda Gates Foundation Grand Challenges Explorations Award

Labs & Collaborations: Dr. Spiegel leads the Spiegel Research Group at Yale, collaborating with institutions like the Yale Cancer Center and Yale Ventures. His work integrates interdisciplinary approaches in chemical biology and translational medicine.