Darin Jones

Darin Jones is an Associate Professor of Pharmaceutical Sciences at the University of Arkansas for Medical Sciences (UAMS) College of Pharmacy. He holds a PhD in Chemistry from the University of Missouri and completed postdoctoral training at the University of California, Riverside. His research focuses on medicinal chemistry and chemical biology, particularly in developing small molecule inhibitors targeting proteins involved in DNA repair processes, anticancer therapies, and radioprotection. He employs structural biology, fragment-based drug design, and computer-aided methods to advance these goals.

Key research areas include DNA repair mechanisms, antiviral strategies against SARS-CoV-2, and the development of radioprotective agents like tocotrienol analogues. Dr. Jones has published extensively on topics such as PARG inhibitors, GRB2 signaling, and novel drug delivery systems. His work bridges basic science and translational medicine, with a focus on overcoming chemotherapeutic resistance and improving therapeutic outcomes.

Recent publications highlight innovations in high-throughput screening methodologies (e.g., HT-SAXS) and structure-based design of enzyme inhibitors. These studies underscore his laboratory's commitment to advancing drug discovery pipelines for complex diseases like cancer and viral infections.