Danique van Rijswijck

Danique van Rijswijck is a Researcher at Utrecht University's Department of Pharmaceutical Sciences within the Faculty of Science. She operates in the Biomolecular Mass Spectrometry and Proteomics research group, focusing on advanced proteomic techniques to investigate antibody repertoires and disease mechanisms. Her work bridges clinical immunology and analytical biochemistry through mass spectrometry applications.

Her research centers on immunoglobulomics and antibody repertoire analysis, with emphasis on personalized immune responses in autoimmune and infectious diseases. She employs LC-MS-based Fab profiling to dissect polyclonal antibody responses at molecular resolution, particularly examining IgG1 and IgA1 clonal dynamics. Key disease contexts include rheumatoid arthritis, systemic sclerosis, and SARS-CoV-2 infection/vaccination responses, where she reveals how individual variations in antibody repertoires influence disease progression and treatment outcomes.

Analysis of her 15 most recent publications shows consistent innovation in mass spectrometry methodologies for antibody profiling, with a strong trend toward understanding hyperpermeability in rheumatoid synovial compartments, DNA-binding mechanisms in systemic sclerosis autoantibodies, and personalized antibody responses to viral variants. Her work consistently demonstrates that human antibody repertoires are highly individualized, dynamic, and clinically significant across multiple disease states.

Danique van Rijswijck is embedded in Utrecht University's Biomolecular Mass Spectrometry and Proteomics team, which develops cutting-edge proteomic technologies for biomolecular analysis. The group specializes in translating mass spectrometry innovations into clinical applications for autoimmune disorders and infectious diseases, with van Rijswijck contributing specifically to antibody repertoire characterization workflows.