Daniel Rosenbaum

Daniel Rosenbaum is a faculty member in the Department of Biophysics at University of Texas Southwestern Medical Center. His research focuses on the structure and function of integral membrane signaling proteins linked to human diseases, particularly G protein-coupled receptors (GPCRs) and sterol transporters.

• Education: Undergraduate in Chemistry at Princeton, PhD in Chemistry at Harvard under David Liu, postdoctoral work at Stanford with Brian Kobilka

His lab employs biophysical techniques such as

• X-ray crystallography
• Cryo-electron microscopy
• NMR spectroscopy

to study structure-function relationships in GPCRs and lipid homeostasis. Recent work includes drug design against orexin and cannabinoid receptors, and structural analysis of sterol transporters.

The trends in his research publications emphasize

• GPCR structure and dynamics
• Membrane protein interactions
• Allosteric modulation
• Ligand-binding mechanisms
• Therapeutic targeting of CNS receptors
• Biophysical methodology development

Dr. Rosenbaum's lab also investigates the molecular basis of sterol homeostasis and the development of labeling strategies for NMR studies of wild-type GPCRs. His work bridges fundamental structural insights with translational applications in drug discovery.