Daniel Roderer

Dr. Daniel Roderer is a Research Group Leader at the Leibniz Research Institute for Molecular Pharmacology (FMP) in Berlin, where he heads the Roderer Group focused on Structural Biology. His research investigates the molecular mechanisms underlying host-microbiome interactions in the human gut, with particular emphasis on bacteria associated with colorectal cancer.

Dr. Roderer's research interests span multiple areas of structural biology and microbiology. His work primarily focuses on understanding how bacterial proteins interact with human host receptors, particularly in the context of colorectal cancer. Using advanced techniques like cryo-electron microscopy (cryo-EM) and single-particle analysis, his group determines the structures of protein complexes that facilitate host-microbiome interactions. His research also includes identifying novel bacterial adhesins and visualizing molecular details of bacteria interacting with host epithelium using cryo-electron tomography (cryo-ET).

• Molecular mechanisms of microbiome-host interactions
• Structural analysis of bacterial adhesins
• Cryo-EM of membrane protein complexes
• Role of gut microbiome in colorectal cancer

Analysis of Dr. Roderer's recent publications reveals a strong focus on structural mechanisms of bacterial toxins and host-pathogen interactions, particularly involving Fusobacterium nucleatum and Tc toxins. His work combines structural biology with microbiology to understand how bacterial proteins bind to host receptors, with implications for developing targeted therapies for colorectal cancer and other microbiome-related diseases.

Dr. Roderer actively mentors several PhD students in his research group, fostering the next generation of structural biologists. His laboratory utilizes cutting-edge cryo-EM technology to visualize molecular interactions at near-atomic resolution.

The Roderer Group operates within the Structural Biology department at FMP, utilizing state-of-the-art facilities for cryo-EM and molecular biology research. The group collaborates with other research teams at FMP and beyond to advance understanding of microbiome-host interactions.