D. Louis Collins

D. Louis Collins is a Professor at the Montreal Neurological Institute, McGill University, specializing in advanced neuroimaging techniques for neurodegenerative diseases. His research spans Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and autism spectrum disorders, with emphasis on quantitative MRI analysis, biomarker development, and computational modeling of disease progression.

His research focuses on:

• Development of automated tools for hippocampal-ventricle ratio analysis and brain age prediction
• Mechanistic studies of tau and amyloid pathology in Alzheimer's disease progression
• Neuroanatomical mapping of genetic frontotemporal lobar degeneration
• Early biomarker discovery in pediatric neurodevelopmental disorders
• Methodological innovations in MRI-ultrasound co-registration and template construction

Analysis of his 15 most recent publications reveals dominant themes in Alzheimer's disease biomarker validation (40%), Parkinson's disease neurodegeneration (20%), neurodevelopmental disorder imaging (15%), and methodological advances in neuroimaging (25%). His work frequently appears in high-impact neurology journals with strong clinical translation focus.

Professor Collins actively contributes to national imaging guidelines through the CCNA Imaging Workgroup and has developed significant neuroimaging resources including the FinnBrain neonatal atlas and MRI-ultrasound co-registration databases. His research bridges computational neuroscience with clinical neurology, emphasizing practical applications for disease diagnosis and monitoring.

Current projects include optimizing clinical trial designs for Alzheimer's therapeutics using simulation-based power analysis, repurposing clinical MRI archives for multiple sclerosis research, and developing sex-specific biomarkers for neurodegenerative diseases. His lab maintains strong collaborations with national and international consortia focused on neurodegenerative and neurodevelopmental disorders.