Curt Scharfe

Curt Scharfe is an Adjunct Associate Professor of Genetics at Yale University's Yale School of Medicine. He holds affiliations with the Center for Biomedical Data Science, Molecular Cell Biology, Genetics and Development, and Molecular Medicine, Pharmacology, and Physiology departments. His academic roles integrate clinical molecular genetics expertise with genomic research.

Education includes an MD from the University of Frankfurt (1996), PhD from the University of Wuerzburg (1998), residency in Pediatric Genetics at LMU Munich (2000), postdoctoral work in Biochemistry at Stanford (2005), and Clinical Molecular Genetics Fellowship at Stanford (2014). He is board-certified by the American Board of Medical Genetics (ABMGG) in Clinical Molecular Genetics.

Research focuses on genomic technologies, neonatal screening, mitochondrial diseases, and cystic fibrosis. Key projects include developing DNA sequencing methods for dried blood spots and advancing metabolomic panels for newborn screening. He collaborates on guidelines for genetic testing reanalysis and contributes to forensic microhaplotype panels.

Recent work includes studies on maternal age effects on newborn metabolic markers and systems biology approaches to hypertension. His lab (Scharfe Lab) innovates in genetic diagnostics and molecular pathology.

Honors include Connecticut Innovations Biopipeline Award (2020), Cystic Fibrosis Foundation grants, and Stanford seed funding. He co-authored over 65 peer-reviewed articles and holds patents on molecular diagnostic technologies.