About
Colin Thorpe is the Willis Harrington Professor in the Department of Chemistry and Biochemistry at the University of Delaware, College of Arts & Sciences. His research focuses on the biochemistry of disulfide bond formation, particularly the enzymology of flavoprotein sulfhydryl oxidases like QSOX1 and ALR. He investigates oxidative protein folding in eukaryotes using techniques such as enzyme kinetics, spectroscopy, and structural biology.
- Education: B.A. (1969, Cambridge University), Ph.D. (1972, University of Kent at Canterbury), Postdoctoral (1973–1978, University of Michigan).
- Research Themes: Disulfide-rich biomaterials (e.g., avian eggshell membranes), redox regulation in cancer progression, and inhibition of oxidative folding pathways.
Article Trends: Recent publications emphasize bioorthogonal chemistry, tumor microenvironment modulation via QSOX1, and advanced imaging techniques for redox states. His work bridges enzymology, structural biology, and biomedical applications.
- Scientific Awards:
- Willis Harrington Professorship
Collaborations: Works with the Polenova laboratory on NMR studies of CREMP and with the Kaiser/Fass groups on Ero1 oxidase mechanisms.
