Clemence Blouet

Dr. Clemence Blouet is a Principal Investigator at the Institute of Metabolic Science, University of Cambridge, affiliated with the MRC Metabolic Diseases Unit and Wellcome Discovery Research Platform. Her research focuses on understanding how the mammalian brain senses nutrients and energy availability to regulate appetite, metabolism, and neuroendocrine functions, particularly in the context of obesity and metabolic diseases.

• Academic Affiliation: Department of Clinical Biochemistry, University of Cambridge
• Lab Focus: Brain nutrient sensing, amino acid homeostasis, oligodendrocyte plasticity, and anti-obesity therapeutic targets
• Key Techniques: Multi-disciplinary approaches including molecular manipulations, neuroanatomical mapping, and metabolic phenotyping

Her recent work has identified leucine-sensing neurons in the nucleus of the solitary tract (NTS) that suppress appetite without inducing aversion, and demonstrated rapid myelin turnover in the median eminence regulated by metabolic cues. Current projects explore synergistic effects of GLP-1 and GIP receptor agonists, oligodendrocyte-mediated nutrient sensing, and brain protein-sensing mechanisms.

Dr. Blouet's research team includes PhD student Ana Parish and multiple research associates. Funding sources include the Medical Research Council and Diabetes UK. Her publications highlight novel pathways in hypothalamic signaling, neuroglial metabolic sensing, and translational strategies for weight loss therapies.