Claudia Rössig

Claudia Rössig is Professor and Director of the Department of Pediatrics and Adolescent Medicine, Pediatric Hematology and Oncology at the University of Münster's Faculty of Medicine. She leads the Rössig Group focused on Cellular Tumor Immunotherapy within the Multiscale Imaging Centre and Cluster of Excellence "Cells in Motion".

Her research pioneers T cell-based immunotherapies for pediatric cancers, with emphasis on overcoming barriers in solid tumors like Ewing sarcoma. She investigates GD2-targeted CAR T cells, tumor microenvironment interactions, and immune evasion mechanisms including HLA-G and PD-L1 expression. Her work bridges preclinical development and clinical translation to enhance efficacy against childhood solid cancers.

Analysis of her 15 most recent publications (2014-2024) reveals consistent focus on CAR T/NK cell engineering for pediatric solid tumors, GD2 targeting, tumor microenvironment modulation, and immune evasion mechanisms. Key trends include cytokine-enhanced CAR designs, epigenetic regulation of tumor antigens, and nanocarrier-based delivery systems for leukemia.

Professor Rössig's laboratory utilizes advanced technologies including semi-automated T cell production systems and multicolor imagers to accelerate immunotherapy development. Her research is driven by clinical needs observed in pediatric oncology practice, with the goal of curing previously untreatable childhood cancers through cellular immunotherapies.