Chrysothemis Brown

Chrysothemis Brown is an Assistant Professor at Weill Cornell Medicine and an Assistant Attending Physician/Assistant Member at Memorial Sloan Kettering Cancer Center (MSK). Her research focuses on antigen-presenting cells (APCs) and their role in immune tolerance, early life immune development, autoimmunity, and cancer immunology.

• Institutional Affiliation: Weill Cornell Medicine & MSK
• Department: Pediatrics
• Academic Rank: Assistant Professor

Education:

• MA, University of Oxford
• MD, Royal Free and University College London
• PhD, King’s College London (Immunology, under Randy Noelle)

Research Interests center on understanding how tissue environments shape immune cell fate and function. Key areas include:

• Mechanisms of immune tolerance to self and commensal antigens during early life
• Role of APCs (e.g., Thetis cells) in mucosal immunity and autoimmunity
• Dendritic cell heterogeneity in tumor immunology

Her lab employs single-cell omics, advanced imaging, and genetically engineered mouse models to bridge human disease research and experimental studies.

Scientific Awards include:

• Persuasive Square Sohn Award (2025)
• Pew Trust Biomedical Scholar (2025)
• NIAID DP2 New Innovator Award (2022)
• V Foundation Scholar (2022)
• Josie Robertson Investigator (2020-2025)

Lab Members include graduate students (Logan Fisher, Yoselin Paucar Iza, Gayathri Shibu) and senior technician Yollanda Franco Parisotto. The lab is affiliated with MSK's Immuno-Oncology Program and the Parker Institute for Cancer Immunotherapy.