Chris Smith

Chris Smith is a Professor in the Department of Biochemistry at the University of Cambridge, leading research on the mechanisms of regulated alternative pre-mRNA splicing. His work combines molecular, biochemical, and computational approaches to study splicing regulators in vascular smooth muscle cells and lymphoid systems. Key research focuses include the master regulator RBPMS, phosphorylation-driven splicing activity, and PTBP1's role in B cell selection.

Research Interests:

• Mechanisms of alternative splicing regulation
• RBPMS's role in smooth muscle cell differentiation
• PTBP proteins in immune cell function
• Global splicing networks and regulatory interactions

Collaborations include Sanjay Sinha (Cambridge Stem Cell Institute), Helle Jørgensen (Department of Medicine), and Martin Turner (Babraham Institute). The group investigates splicing's role in cell-specific phenotypes and disease relevance.

Lab activities include transcriptomic, proteomic, and structural studies. Contact: cwjs1@cam.ac.uk