Chih-Sheng Jason Chiang

Dr. Chih-Sheng Jason Chiang is an Assistant Clinical Professor in the Department of Radiological Sciences at the David Geffen School of Medicine, University of California Los Angeles (UCLA). His work bridges biomedical engineering and clinical medicine, focusing on translational research that directly impacts patient care in interventional oncology.

Dr. Chiang's educational background includes:

• Residency in Interventional Radiology from UCLA (2022)
• MD in Medicine from University of Wisconsin (2016)
• PhD in Biomedical Engineering from University of Wisconsin (2014)
• BS in Biomedical Engineering from Johns Hopkins University (2007)

Dr. Chiang's research focuses on interventional oncology, particularly using minimally-invasive image-guided techniques to treat solid tumors. His lab employs a three-pronged approach: 1) Computer simulation of medical devices and biological environments; 2) Validation using phantom, ex-vivo, and in-vivo models; 3) Optimization of devices and techniques for clinical implementation. His work spans thermal ablation, immunotherapy, numerical simulation, and medical device development, with a special focus on hepatocellular carcinoma treatment.

Analysis of Dr. Chiang's recent publications reveals a strong focus on hepatocellular carcinoma treatment using image-guided ablation techniques combined with immunotherapy. His research increasingly integrates artificial intelligence for treatment prediction and combines thermal ablation with NK cell-based immunotherapy to overcome treatment resistance. Much of his work utilizes porcine models to validate techniques before clinical translation.

Dr. Chiang has received several notable awards:

• Phillips/RSNA Fellow Research Grant from UCLA (2020)
• Magna Cum Laude Educational Exhibit Award at the RSNA Annual Meeting (2017)
• RSNA Trainee Research Prize from University of Wisconsin-Madison (2011)
• Fulbright Grant from Tieraerztliche Hochschule Hannover, Germany (2007)

Dr. Chiang mentors several students and researchers in his lab, including medical students, PhD candidates, and undergraduate researchers. His lab has recently graduated Justin Lee (MD, PhD), Cathy Chen (PhD), Aravinth Ruppa (BS), and Hannah Mirmohammadi (BS). His research is supported by multiple grants including an NIH R21 grant for "Light-Activated SIte-Specific Conjugation," a UCLA OPSCD Bridge Grant, and an RSNA Research Scholar grant for "Augmenting Microwave Ablation with Supercharged NK cells."

The Chiang Lab is a multi-disciplinary group that collaborates extensively with the UCLA School of Engineering and School of Medicine. They leverage engineering principles to solve clinical problems in interventional oncology, with a particular focus on improving thermal ablation outcomes for liver cancer patients. The lab recently established an Oncopig liver tumor model to better study cancer therapies.