Chad A. Shaw

Chad A. Shaw, Ph.D. is a Professor in the Department of Molecular & Human Genetics at Baylor College of Medicine and a Joint Professor in the Department of Statistics at Rice University. He serves as Director of the D2K Laboratory at Rice University and is affiliated with the Jan and Dan Duncan Neurological Research Institute, Stem Cells and Regenerative Medicine (STaR) Center, and Graduate Program in Quantitative & Computational Biosciences at Baylor College of Medicine.

• Education:
  • BS in Mathematics, Duke University (1995)
  • PhD in Statistics, Rice University (2001)

Research Interests: Dr. Shaw specializes in statistical genomics, bioinformatics, and systems biology, with expertise in next-generation sequencing, copy-number analysis, multi-omic data integration, and gene expression profiling. His work on structural variation and repetitive elements has advanced understanding of genetic recurrence risk related to parent of origin, somatic mosaicism, and paternal age.

Publications: His ~200 peer-reviewed articles focus on genomic disorders, variant analysis, and computational tools, with recent studies on spliceosome targeting in cancer, LINE element recombination, and eQTL mapping. The 2020 article Bayesian modelling of high-throughput sequencing assays with malacoda highlights his work in computational variant detection.

Teaching & Leadership: Dr. Shaw trains Ph.D. students in high-dimensional statistics, Mendelian disease modifiers, and variant prioritization. He chairs the qualifying exam committee for the Quantitative and Computational Biosciences program and collaborates extensively with institutions like Jan and Dan Duncan Neurological Research Institute and Human Genome Sequencing Center.