About
Carol Lange, PhD is a Professor of Medicine and Pharmacology at the University of Minnesota with a joint appointment in the Division of Hematology, Oncology, and Transplantation. Her research bridges molecular endocrinology, cancer biology, and pharmacology, focusing on steroid hormone receptor signaling in hormone-driven cancers.
- Breast Cancer
- Steroid Hormone Receptors
- Cancer Stem Cells
- Signal Transduction
- Endocrine Resistance
- Cancer Metabolism
Recent studies highlight her work on progesterone receptor isoform-specific regulation of super enhancers in breast cancer stem cell expansion, glucocorticoid receptor interactions with TGFβ signaling in triple-negative breast cancer, and clinical trials targeting endocrine resistance. These investigations align with emerging themes in tumor microenvironment dynamics and hormone receptor crosstalk.
Key collaborations include the SMILE Study (Onapristone + Fulvestrant for ER+/HER2- metastatic breast cancer) and the ONAWA (SOLTI-1802) trial evaluating antiprogestin therapy. Her work also explores metabolic reprogramming, PDK4 activation, and epigenetic regulation in therapy-resistant populations.
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