Carol Artlett

Carol Artlett, PhD, is an Associate Professor in the Department of Microbiology & Immunology at Drexel University College of Medicine. Her research focuses on fibrosis mechanisms, particularly in systemic sclerosis (SSc), emphasizing inflammasome signaling, collagen export pathways, and miR-155 regulation. She investigates therapeutic development for fibrotic diseases and chronic wound healing, leveraging small molecule compounds and biotech collaborations.

Education:

• PhD - University of London (1996)

Research Interests:

• Inflammasome signaling pathways
• Role of miR-155 and IL-1 in fibrosis progression
• Procollagen export via TANGO1/cTAGE5 proteins
• Anti-fibrotic drug development targeting ER-Golgi transport
• Chronic wound healing mechanisms
• Systemic sclerosis pathogenesis

Key Contributions:

• Identified TANGO1 as critical for fibrosis-related collagen secretion
• Developed anti-fibrotic small molecule targeting ER protein export
• Discovered caspase-1's role in inflammasome-driven fibrosis
• Validated acALY18 peptide's anti-fibrotic potential
• Studied NLRP3 inflammasome regulation in fibroblasts

Labs/Teams:

Leads a multidisciplinary lab focusing on translational research in fibrosis mechanisms, collaborating with biotech firms to advance therapeutic candidates. Research integrates cellular immunology, molecular biology, and preclinical drug testing.