Bryan Sun

Dr. Bryan Sun is Associate Professor in Dermatology at UC Irvine with joint appointment in Biological Chemistry. As Director of Faculty Development in Research, he leads investigations into epidermal biology and skin disease mechanisms using genomic and computational approaches.

Research focuses on regulatory roles of non-coding RNAs in skin development, CRISPR-based functional genomics of epidermal differentiation, and inflammatory signaling in dermatologic conditions. Recent work employs spatial transcriptomics and machine learning for skin disease biomarker discovery.

Publications demonstrate consistent methodology development in RNA biology applications for dermatology, with emphasis on keratinocyte regulation, alternative splicing mechanisms, and translational implications for inflammatory disorders.

Technical Innovations:

• CRISPR screening platforms for epidermal biology
• Spatial multi-omics integration techniques
• Computational models of RNA regulatory networks