Bruce E. Vogel

Bruce E. Vogel, PhD, is an Assistant Professor in the Department of Pharmacology & Physiology at the University of Maryland School of Medicine. He leads a research program investigating Age-related Macular Degeneration (AMD) using C. elegans models, focusing on complement factor H (CFH) interactions with sensory neuron structures. His lab employs molecular genetics, CRISPR-Cas9, and advanced microscopy techniques to study extracellular matrix biology.

Education:

• B.A. in Biochemistry, Rutgers College
• Ph.D. in Biochemistry, Robert Woods Johnson Medical School/Rutgers University
• Postdoctoral training: Sanford Burnham Prebys Medical Discovery Institute and Johns Hopkins University

Research Focus: Dr. Vogel's work centers on AMD pathogenesis mechanisms, particularly CFH's role in maintaining photoreceptor integrity. His team explores conserved interactions between CFH, heparan sulfate proteoglycans, and cytoskeletal proteins in sensory neurons. Current NIH-funded projects (R01EY032868) aim to identify CFH-dependent cell surface receptors and develop therapeutic strategies.

Publication Trends: Recent articles (2021-2022) reflect dual expertise in extracellular matrix biology and microbial resistance mechanisms. Earlier work established foundations in cytokinesis regulation, ECM assembly, and protein misfolding. Research consistently integrates genetic models with structural biochemistry across diverse physiological contexts.

Grants:

• NIH R01EY032868: 'Molecular genetics of a complement factor H homolog' (2021-2026, 30% effort)

Laboratory: Located in BioMET 307B, the Vogel Lab utilizes forward/reverse genetic screens, protein biochemistry, live-cell imaging, and behavioral assays in C. elegans to study sensory neuron degeneration mechanisms relevant to human blindness.