Bruce Bissonnette

Dr. Bruce Bissonnette is an Associate Professor at the University of Chicago Pritzker School of Medicine, specializing in Gastroenterology within the Department of Medicine. His clinical expertise spans diagnosis and management of gastrointestinal disorders such as

• Barrett’s esophagus
• Inflammatory Bowel Disease
• Colorectal Cancer
• Peptic Ulcer Disease

and related conditions.

Education & Training:

• Internship: Philadelphia Naval Hospital (1976)
• Residency: Hospital of the University of Pennsylvania (1980)
• Fellowship: Hospital of the University of Pennsylvania (1981)
• Clinical Staff Fellow: NIADDK, NIH (1984)
• Faculty: University of Chicago (1990–Present)

Research Interests focus on colon cancer pathogenesis and chemoprevention, particularly the role of Western diets, fish oil, and signaling pathways (ADAM17-EGFR, CXCL12-CXCR4) using

• Animal Models
• Human Tissue Cultures
• Colonic Organoids
• In Vitro Systems

His lab is developing a liquid biopsy for early CRC detection via 5-hydroxymethylcytosine biomarkers with Dr. Chuan He and Dr. Wei Zhang. He also investigates Ythdf1 in immune-mediated tumor suppression and the pro-renin receptor (Atp6ap2) in tumor suppression via vitamin D and RAS inhibition, collaborating with Dr. Yan Chun Li.

Publication Trends span biochemistry, molecular biology, and cancer research, emphasizing

• Signal Transduction
• miRNA Regulation
• VDR-EGFR Cross-Talk
• Proteomic Interactions

with over 15 high-impact studies since 2014.