Brian Sheridan

Brian Sheridan is an Associate Professor in the Department of Microbiology and Immunology at Stony Brook University, focusing on T cell immunity in gastrointestinal mucosal tissues to develop vaccination strategies against foodborne pathogens.

Education:

• Ph.D. in Immunology, University of Pittsburgh School of Medicine, 2008

Research Interests:

Dr. Sheridan's laboratory investigates T cell memory regulation in barrier tissues using foodborne infection models. Key areas include:

• Memory CD8 T cells: BATF3 transcription factor's dual role in memory development and licensing of resident memory T cell formation in gut tissues.
• Memory γδ T cells: Antigen specificity profiling, multifunctional IL-17A/IFNγ responses, and pathogen subversion mechanisms by Yersinia spp.
• Vaccine Development: Oral Listeria-based cancer vaccine platforms assessing immunogenicity and efficacy compared to intravenous delivery.

His work bridges fundamental immunology with applications for infectious disease prevention, inflammatory bowel disorders, and gastrointestinal oncology.

Dr. Sheridan leads research within Stony Brook's Center for Infectious Diseases, utilizing Listeria monocytogenes, Salmonella enterica, and Yersinia pseudotuberculosis infection models to dissect conventional and unconventional T cell responses.