Brian R. Smith

Brian R. Smith is Professor of Laboratory Medicine, Biomedical Engineering, Internal Medicine (Hematology) and Pediatrics at Yale University. He serves as Deputy Dean for Clinical and Translational Research at the Yale School of Medicine, Co-Director of the Yale Center for Clinical Investigation, and Chair of the Department of Laboratory Medicine. Dr. Smith is also Chief of Laboratory Medicine and Attending Physician at Yale New Haven Hospital, as well as an attending physician at the Connecticut VA Medical Center and Bridgeport Hospital.

Dr. Smith's research focuses on the inflammation-hemostasis interface, particularly in relation to biomaterials, and cellular immunotherapeutics. His work spans the full translational spectrum from basic wet bench research through clinical and epidemiological trials (T1-T4). He has been continuously funded by the NIH at the PI-level for over 35 years, demonstrating sustained excellence in translational research. His investigations have particular emphasis on hematologic malignancies, diagnostic accuracy, and the educational frameworks needed to train future laboratory medicine specialists.

Analysis of Dr. Smith's publications reveals a consistent focus on advancing laboratory medicine through both clinical research and educational innovation. His work addresses critical issues in diagnostic accuracy, physician-scientist training pathways, and the integration of new technologies into clinical practice. The publications span oncology, hematology, medical education, and healthcare systems, reflecting his interdisciplinary approach to advancing laboratory medicine.

• Evans Award for Outstanding Contributions to Laboratory Medicine (2010)
• President, Academy of Clinical Laboratory Physicians & Scientists (2007-2008)
• Chair (elected), Research Committee and Member of the Council, Association of Pathology Chairs (2010)

Dr. Smith has been instrumental in developing Yale's research infrastructure, overseeing implementation of research core facilities in Translational Immune Monitoring, Flow Cytometry, and Clinical Sample Real Time Acquisition. He chairs the Clinical Research Technology Committee and has guided the development of a Cellular Therapy core resource. As an educator, he has personally mentored over 50 MD, MD/PhD, and PhD trainees, most of whom hold tenure-track positions. He is the initiator and long-standing PI of Laboratory Medicine's post-doctoral T32 training program in Immunohematology.

Dr. Smith has played a key national role in laboratory medicine education, developing curricula and physician-scientist training paradigms. Through his leadership in the Association of Pathology Chairs, he helped establish a specific Physician-Scientist residency pathway with the American Board of Pathology, addressing a critical need for specialized training in academic pathology.