Brian Miller

Brian Miller, M.D., MBA, MPH, is an Assistant Professor of Medicine and Business (courtesy) at Johns Hopkins University. He is a practicing hospitalist, health policy researcher, and consultant to the FTC Bureau of Consumer Protection on health insurance. He serves on the Medicare Evidence Development & Coverage Advisory Committee. His research focuses on immune regulation mechanisms in cancer, tumor microenvironment dynamics, and overcoming resistance to immunotherapy. He holds advanced degrees in medicine, business administration, and public health.

Research Interests: Dr. Miller’s work bridges immunology and oncology, investigating how cellular exhaustion and tumor microenvironment factors influence cancer therapy efficacy. Key areas include T cell dysfunction in aging, epigenetic modulation of PD-1 pathways, and synthetic lethal approaches to drug resistance in prostate cancer. He also explores the impact of health policies on access to immunotherapies.

Recent Work Trends: His publications emphasize mechanisms of immunotherapy resistance (e.g., ATF4 in CD8+ T cells), the role of myeloid cells in tumor evasion, and combining therapies like denosumab with checkpoint inhibitors. His 2024 studies highlight age-related T cell contraction and epigenetic strategies to enhance antitumor immunity.

Consulting & Policy: As an FTC advisor, he addresses health insurance market challenges, while his Medicare committee role informs coverage decisions for emerging cancer treatments.