Brian L. Lin

Brian L. Lin, PhD is an Assistant Professor in the Department of Cell Biology, Neurobiology, and Anatomy at the Medical College of Wisconsin. His research focuses on mechanical signaling in the heart within muscular dystrophy contexts, addressing cardiac dysfunction which is a leading cause of mortality in these diseases. He holds a PhD from Loyola University (2016) and a BS from Miami University (2008), with postdoctoral training at Johns Hopkins Medical Institutions (2016-2023).

Education:

• BS, Miami University, 2008
• PhD, Loyola University, 2016
• Postdoctoral Fellow, Johns Hopkins Medical Institutions, 2023

Research Focus: The Lin Lab employs spatial transcriptomics, animal models, single-cell biomechanics, and nanoparticle drug delivery to develop therapies targeting TRP channels in dystrophic cardiomyopathy. Key areas include cardiac mechanical signaling, TRPC6 channel inhibition, and stem cell engineering for regenerative medicine.

Publications: Recent work emphasizes drug discovery (e.g., ruxolitinib repurposing), gene therapy limitations, cadmium toxicity effects, and TRP channel pharmacology. Publications span Science Translational Medicine, Cell Reports, and iScience.

Awards:

• K99/R00 Award (TRPC6 in Duchenne Muscular Dystrophy)

Lab & Collaborations: The lab integrates multi-omics approaches with preclinical testing platforms. Current projects explore novel therapies using in silico drug discovery and human stem cell models. Follow @iheartlinlab for updates.