Brian E Nolan

Brian E Nolan, MD, is an Assistant Professor in the Department of Pediatrics at Northwestern University's Feinberg School of Medicine, specializing in Pediatric Rheumatology at Ann & Robert H. Lurie Children's Hospital of Chicago, focusing on complex immune disorders.

Dr. Nolan's educational background includes:

• BA from Swarthmore College (2005)
• MD from Case Western Reserve University School of Medicine (2013)
• Pediatrics Internship at Children's National Healthcare System (2014)
• Pediatrics Residency at Children's National Healthcare System (2016)
• Pediatric Rheumatology Fellowship at Children's Hospital of Philadelphia (2019)

His research centers on autoimmunity-immunodeficiency interplay, targeting rapid diagnosis and treatment of rare autoinflammatory syndromes. Key areas include:

• Periodic fever syndromes
• Chronic recurrent multifocal osteomyelitis (CRMO)
• Hemophagocytic lymphohistiocytosis (HLH)
• Genomic medicine applications in immune disorders

Recent publications reveal strong translational focus on genomic mechanisms in immune dysregulation, featuring:

• PU.1 mutation analysis in agammaglobulinemia
• Institutional implementation of multidisciplinary care models
• Immune mechanisms in sepsis-associated organ failure

Professional recognition includes:

• Distinguished Fellow, American College of Rheumatology (2019)

Dr. Nolan actively contributes to medical education and serves on the American College of Rheumatology Government Affairs Committee (2025-present), with memberships in ACR and CARRA driving collaborative research. He co-develops specialized multidisciplinary programs for immune dysregulation disorders, integrating rheumatology, immunology, and critical care expertise to manage complex pediatric cases through team-based institutional models.