Brett Mansfield

Dr. Brett Mansfield serves as a Lecturer in Endocrinology at the University of the Witwatersrand, Johannesburg, where he bridges clinical practice with research in metabolic disorders and endocrine pathology. His work addresses critical gaps in dyslipidemia management and endocrine-related infectious complications within resource-constrained settings.

His academic credentials include:

• BSc
• MB BCh (Bachelor of Medicine, Bachelor of Surgery)
• MMed (Master of Medicine)
• MSc(Med) from the University of Edinburgh
• FCP(SA) (Fellow of the College of Physicians of South Africa)

Dr. Mansfield's research spans lipidology, diabetology, and endocrine-infectious disease intersections. He investigates novel therapies for homozygous familial hypercholesterolemia, dyslipidemia in thyroid disorders, pancreatic beta cell replacement, and rare endocrine tumors. His clinical work emphasizes South African patient populations, particularly regarding access barriers to emerging lipid-lowering treatments.

Analysis of his 15 most recent publications reveals three dominant research thrusts: (1) Development and accessibility of PCSK9 inhibitors and ANGPTL3-targeted therapies for severe dyslipidemia, (2) Unique manifestations of endocrine disorders in HIV-affected patients including IRIS-related complications, and (3) Context-specific challenges in managing metabolic diseases within South Africa's healthcare infrastructure. His work consistently integrates clinical observations with translational research approaches.