Bojie Cong

Dr. Bojie Cong is a Researcher at the University of Glasgow's School of Cancer Sciences, working within the Cancer Sciences department under the mentorship of Prof. Ross Cagan. His research is centered at Garscube Campus in Bearsden, focusing on molecular mechanisms of cancer progression and therapeutic resistance.

His research program investigates drug resistance pathways in colorectal cancer, with particular emphasis on

• KRAS-mutant tumor evasion via metabolic reprogramming
• WNT/NF-κB signaling crosstalk in treatment failure
• Evolutionary conservation of cell competition mechanisms from Drosophila to mammals
• JNK/Yorkie-driven tumor malignancy through nutrient transporter induction

His work bridges basic Drosophila genetics with translational oncology to identify novel therapeutic vulnerabilities.

Cong's publication trajectory (2018-2025) demonstrates deepening focus on metabolic adaptation in therapy-resistant tumors, evolving from foundational Drosophila studies (2018-2021) to current human colorectal cancer models (2023-2025). The recurring themes across his work include stress-response pathways (JNK), oncogenic signaling (Yorkie/YAP), and metabolic rewiring as central drivers of treatment evasion.

He currently leads the Tenovus Scotland-funded project "Identifying factors that regulate glucuronidation-dependent drug resistance in human colorectal cancer" (2024-2025), indicating active grant support for his research program. While no formal students are listed, his collaborative publications involve multi-investigator teams including Prof. Ross Cagan (primary collaborator), Oliver Maddocks, and Owen Sansom.

Cong maintains active laboratory operations within Prof. Cagan's research group at the University of Glasgow, utilizing integrated approaches spanning Drosophila genetics, mammalian cell models, and clinical cancer datasets to dissect resistance mechanisms.