Benoit Coulombe

Benoit Coulombe is a Professor and researcher at the Université de Montréal's Department of Biochemistry and Molecular Medicine, affiliated with the Montreal Clinical Research Institute (IRCM). He holds the Bell-Bombardier Excellence Chair and directs the Translational Proteomics Research Unit at IRCM. His academic career includes roles as a postdoctoral researcher at the University of Toronto and Université libre de Bruxelles, followed by professorships at Université de Montréal since 2001.

His research focuses on protein-protein interactions, RNA polymerase II transcription regulation, and molecular chaperones. Key projects include developing tools like MAGPIE (machine learning for protein interactions) and investigating leukodystrophies caused by RNA polymerase III mutations. He has published over 100 articles, with work cited over 8,300 times.

Recent studies highlight drug discovery targeting the PAQosome complex, mechanisms of hypomyelinating disorders, and precision medicine approaches. Collaborations include IVADO and Génome Québec for clinical trial transparency initiatives.

Awards include leadership in the IRCM's Responsible Conduct of Research program and contributions to open-access science. His lab integrates proteomics, bioinformatics, and molecular biology to advance disease understanding and therapeutic development.