Benjamin Judkewitz

Benjamin Judkewitz is a Professor at Humboldt University of Berlin and a principal investigator in Collaborative Research Center 1315 (SFB 1315), focusing on inhibitory control of memory consolidation in the primary somatosensory cortex. His work bridges advanced optical engineering with fundamental neuroscience to overcome deep-tissue imaging limitations and investigate cortical dynamics.

His research centers on Neuroscience, Optical Imaging, and Microscopy, with specific expertise in wavefront-shaping techniques (F-SHARP) for deep brain imaging and the neural mechanisms governing brain state transitions. He investigates how cortical pyramidal neurons integrate thalamocortical inputs, neuromodulation, respiration, and movement to drive global state changes from sleep to wakefulness.

Analysis of his 2020-2021 publications reveals two convergent research thrusts: (1) development of three-photon F-SHARP microscopy enabling high-resolution imaging beyond 400μm depth in mouse brain tissue, and (2) theoretical frameworks for multi-pathway brain state regulation. These works demonstrate an interdisciplinary fusion of optical physics, neurophysiology, and systems-level analysis to address fundamental limitations in neural observation.

Dr. Judkewitz leads a research group within SFB 1315 that collaborates intensively with Matthew Larkum's and James Poulet's teams. His laboratory specializes in in vivo multiphoton imaging of dendritic structures in sensory cortices, utilizing custom-modified commercial microscopes for deep-tissue neural circuit analysis.

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