Benjamin J. Frisch

Benjamin J. Frisch, Ph.D., holds the position of Assistant Professor at the School of Medicine and Dentistry with appointments in:

• Department of Pathology and Laboratory Medicine
• Department of Biomedical Engineering

His research career, active since 2007, has a translational focus on microenvironmental support for hematopoietic stem cells (HSCs) in both homeostatic and stressed hematopoiesis, with implications for malignant hematopoiesis such as acute myeloid leukemia.

Dr. Frisch's current research investigates alterations of the bone marrow microenvironment induced by myeloid malignancies, leading to the identification of chemokine CCL3 as a potential therapeutic target for acute myeloid leukemia. Future work aims to further characterize the interactions between malignant hematopoiesis and the bone marrow microenvironment for clinical translation.

His publication record from 2006 to 2019 demonstrates a consistent focus on hematopoietic stem cell biology and the bone marrow niche. Key themes include the role of signaling pathways (Notch, prostaglandin E2, chemokines) and cellular components (osteoblasts, osteocytes) in regulating hematopoiesis and their dysregulation in leukemia, with an emphasis on identifying novel therapeutic targets.