Arthur Weiss

Arthur Weiss is a Professor at the University of California San Francisco (UCSF), where he leads groundbreaking research in immunology and signal transduction in lymphocytes. His work spans over 40 years, focusing on T cell antigen receptor signaling, tyrosine kinases, and phosphatases.

• Education: Ph.D. in Immunology (University of Chicago, 1978), M.D. in Medicine (University of Chicago, 1979)

Weiss's research explores the molecular mechanisms of TCR signaling, including the role of ZAP-70, CD45, and Csk in immune responses, autoimmunity, and cancer. His lab pioneered CAR-T cell development using zeta chain chimeric receptors.

Recent publications highlight his work on Nir3's role in T cell development, ZAP-70's impact on autoimmunity, and TCR signaling modulation in autoimmune arthritis. Awards include the Howard Holley Research Prize, National Academy of Sciences membership, and AAI Distinguished Fellow status.

• Scientific Advisory Roles: Biotechnology companies (Sugen, Pfizer, Plexxikon, Nurix Therapeutics)
• NIH Funding: Multiple grants (T32AR079068, R37AI114575, P01AI091580, etc.)

Weiss's lab established mouse models for ZAP-70, Csk, and CD45 mutations, advancing understanding of lymphocyte signaling in health and disease.