Anne Hinderliter

Anne Hinderliter is a Professor in the Swenson College of Science and Engineering at the University of Minnesota Duluth, specializing in membrane biophysics with research focused on lipid-protein interactions and membrane signaling mechanisms.

Education:

• Ph.D., Cornell University (1994)

Research Interests: Dr. Hinderliter investigates membranes as self-organized systems where lipid chemical structure variations (e.g., acyl chain length) create ripple effects through nearest-neighbor interactions, altering local lipid composition and protein recruitment. Her work emphasizes predictive modeling of membrane-localized binding interactions, evolving from fundamental signal transduction studies to pharmacological and material science applications. She aims to define pathological membrane interactions for developing diagnostic and therapeutic systems.

Publication Trends: Her 2011-2018 publications consistently explore biophysical mechanisms of membrane-associated proteins (particularly synaptotagmin and annexins), integrating calorimetry, computational modeling, and experimental approaches. Key themes include lipid domain formation, calcium-dependent binding, protein conformational changes, and the role of weak interactions in membrane signaling amplification across neurological and cellular repair contexts.