Ann Harris

Ann Harris is a Professor in the Department of Genetics and Genome Sciences at the School of Medicine, Case Western Reserve University. She is a member of the Cancer Genomics and Epigenomics Program at the Case Comprehensive Cancer Center, focusing on tissue-specific and temporal regulation of gene expression in health and disease.

• Primary research on CFTR gene regulation in epithelial diseases like cystic fibrosis (CF) and cancer
• Investigates 3D chromatin architecture and transcriptional networks in CFTR regulation
• Current projects include CFTR mechanisms in understudied tissues (pancreas, gall bladder) and prenatal CF disease progression using CF sheep models
• Applies advanced functional genomics techniques: single-cell RNA-seq, multiomics, spatial transcriptomics, and organoid assays

Her work enhances understanding of epithelial cell biology and provides insights for CF treatment strategies.