Andrew Paek

Andrew Paek is an Associate Professor in the Department of Molecular & Cellular Biology at the University of Arizona. His research integrates molecular biology, computational methods, and live-cell imaging to study cellular decision-making in cancer and tissue homeostasis. His lab is located in Life Sciences South Building (room 331 for office, 310/314 for labs). Key research focuses include oxidative stress responses, transcription factor dynamics, and organoid-based disease modeling.

Research interests span molecular mechanisms of cancer progression, signal transduction pathways (e.g., EGFR, FOXO, β-catenin), and redox biology. His work combines experimental approaches with mathematical modeling and AI-driven image analysis to understand how cells process stress signals and make fate decisions. Notable contributions include identifying peroxiredoxin-mediated transcription timing and ERK signaling dynamics in stem cell regulation.

Publications emphasize translational potential, such as developing organoid platforms for colon research and discovering therapeutic targets via systems biology approaches. His lab actively explores sulfur restriction-based cancer therapies and novel drug combinations using chaperoned machine learning frameworks.