Andrew J. Darwin

Andrew J. Darwin is a Professor in the Department of Microbiology at NYU Langone Health. His research focuses on bacterial pathogenesis, particularly the role of proteases and stress response systems in Pseudomonas aeruginosa and Yersinia enterocolitica. His work explores cell envelope dynamics, proteolytic regulation, and bacterial virulence mechanisms.

• Academic Rank: Professor
• University: NYU Langone Health
• Email: andrew.darwin@nyulangone.org

Dr. Darwin's research investigates protease activation mechanisms, such as CtpA hexameric assembly in Pseudomonas aeruginosa, and stress responses like the Psp system in Yersinia enterocolitica. He examines how proteases regulate cell wall homeostasis, mucoidy, and antibiotic resistance, as well as the interplay between secretion systems and bacterial survival during infections.

Recent publications highlight protease-regulated cell envelope stress responses, including novel activation mechanisms for CtpA protease (2024) and inhibitor systems for lytic transglycosylases (2023). His work spans structural biology, enzymology, and bacterial physiology, with a focus on chronic infection models and virulence strategies.