Andrew Hsieh

Dr. Andrew Hsieh, MD is a Professor and Associate Director in the Human Biology Division at Fred Hutchinson Cancer Center, with concurrent appointments as Professor in the Clinical Research Division at Fred Hutch and Professor in the Division of Hematology and Oncology at the University of Washington School of Medicine. He also serves as Affiliate Faculty in Genome Sciences at the University of Washington.

His research focuses on protein synthesis deregulation in cancer, particularly how transcriptional-translational conflicts and mRNA translation control mechanisms drive prostate and bladder cancer progression. Key areas include:

• Role of 5' UTR mutations in oncogenic translation
• Chromatin remodelers' impact on ribosome speed
• m6A RNA modifications in cellular differentiation
• Translational vulnerabilities in urothelial carcinomas

His laboratory employs multiplexed functional genomic approaches like PLUMAGE to identify druggable targets, with recent work revealing novel mechanisms in advanced prostate cancer. The team bridges fundamental discoveries in translational control with clinical applications through collaborations with the Beronja Lab and Paddison Lab.

Awards include:

• Harrington Scholar-Innovator Award (2024) for developing experimental compounds into anti-cancer drugs

Dr. Hsieh maintains active clinical engagement through the Prostate Cancer Clinic while leading a rapid autopsy program for bladder cancer research. His lab has developed patient-derived xenografts and primary cell models to study metastatic heterogeneity, with recent publications in Cancer Cell and Nature Communications highlighting therapeutic implications of translation deregulation.

He leads the clinical trial 'Protein Synthesis Dynamics in Advanced Bladder Cancer' and mentors the next generation of cancer biologists through Fred Hutch's training programs.